Immune Function

Exploring the Link Between Vaping and Angular Cheilitis: Can NMN Supplementation Offer Relief?”

Angular cheilitis (AC) is an inflammatory condition affecting the corners of the mouth, often resulting from a combination of factors including nutritional deficiencies, systemic conditions, and environmental exposures[1][2]. Vaping has been suggested as a potential cause of angular cheilitis due to its impact on the oral environment. Vaping can dry out the mouth and alter the oral microbiome, potentially leading to conditions favorable for the development of AC. The heat and chemicals from vaping may also irritate the skin around the mouth, exacerbating the condition[1].

Nicotinamide mononucleotide (NMN) is a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme involved in cellular metabolism and energy production. NMN has been studied for its potential to boost immunity and promote healing[4]. By enhancing NAD+ levels, NMN may improve cellular repair processes and immune function, which could help in reducing the frequency and severity of angular cheilitis episodes[4]. The role of NMN in boosting immunity is linked to its ability to support cellular energy production and repair, which is crucial for maintaining a robust immune response[4].

While NMN shows promise, further research is needed to confirm its efficacy in treating conditions like angular cheilitis.

Sources
[1] Angular Chelitis – StatPearls – NCBI Bookshelf https://www.ncbi.nlm.nih.gov/books/NBK536929/
[2] [PDF] Angular Cheilitis, Part 2: Nutritional, Systemic, and Drug-Related … https://cdn.mdedge.com/files/s3fs-public/Document/September-2017/088010027.pdf
[3] [PDF] ESPEN micronutrient guideline https://www.espen.org/files/ESPEN-Guidelines/ESPEN_micronutrient_guideline.pdf
[4] Micronutrient Deficiency in Inherited Metabolic Disorders Requiring … https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10707160/
[5] ESPEN micronutrient guideline – ScienceDirect.com https://www.sciencedirect.com/science/article/pii/S0261561422000668
[6] [PDF] Guidelines on food fortification with micronutrients – IRIS https://iris.who.int/bitstream/handle/10665/43412/9241594012_eng.pdf?sequence=1
[7] Vitamin Deficiency – an overview | ScienceDirect Topics https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/vitamin-deficiency
[8] ESPEN micronutrient guideline – Clinical Nutrition https://www.clinicalnutritionjournal.com/article/S0261-5614%2822%2900066-8/fulltext

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