The Link Between NAD+ and Immune System Health: What You Need to Know

As we age, our immune system begins to decline, leaving us more susceptible to infections and diseases. This decline is due in part to the decrease in NAD+ levels in our bodies. NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in all living cells, and plays a critical role in various biological processes, including energy production, DNA repair, and immune function.

Understanding NAD+

NAD+ is essential for the proper functioning of our immune system. It helps to regulate the production of inflammatory cytokines, which are proteins that play a key role in the immune response. As we age, NAD+ levels decline, which can lead to decreased immune function and increased susceptibility to infection and disease. In addition, lower NAD+ levels have been linked to age-related conditions such as Alzheimer’s disease, diabetes, and cancer.

The Role of NAD+ in Immune System Health

Research has shown that NAD+ plays a critical role in the function of immune cells, such as T cells and macrophages. These cells are responsible for recognizing and destroying foreign invaders, such as viruses and bacteria. NAD+ helps to regulate the activity of these cells, ensuring that they respond appropriately to threats without overreacting and causing damage to healthy tissue.

In addition, NAD+ is involved in the process of autophagy, which is the body’s natural way of cleaning out damaged cells and regenerating new ones. This process is crucial for maintaining a healthy immune system, as it helps to remove dysfunctional immune cells and replace them with new, functional ones.

Boosting NAD+ Levels for Immune System Health

Given the crucial role that NAD+ plays in immune system health, it is important to find ways to boost NAD+ levels as we age. One way to do this is through the use of NAD+ precursor molecules, such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). These molecules are converted into NAD+ in the body, helping to replenish NAD+ levels and support immune system function.

In addition to NAD+ precursors, there are other ways to support NAD+ levels, such as through a healthy diet and regular exercise. Certain nutrients, such as vitamin B3, play a role in NAD+ production, so ensuring that you are getting an adequate intake of these nutrients can help to support NAD+ levels. Exercise has also been shown to increase NAD+ levels, making it an important component of overall immune system health.

The Future of NAD+ and Immune System Health

As we continue to learn more about the role of NAD+ in immune system health, there is great potential for the development of new therapies and interventions to support immune function as we age. Research is ongoing to further understand how NAD+ supports immune cells and how we can optimize NAD+ levels to maintain a healthy immune system.

Additionally, there is growing interest in the potential use of NAD+ and NAD+ precursors as a way to support immune function in individuals with immune system disorders or compromised immune systems. By understanding the link between NAD+ and immune system health, we may be able to develop new treatments for a range of immune-related conditions.


As we age, our immune system naturally declines, leaving us more vulnerable to infections and diseases. NAD+ plays a critical role in supporting immune system health, and as NAD+ levels decline with age, it is important to find ways to support NAD+ levels to maintain a healthy immune system. By understanding the link between NAD+ and immune system health, we can work towards developing new strategies to support immune function and improve overall health and longevity.

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