Acetyl Tetrapeptide-5 (Eyeseryl)

Understanding the Mechanism of Action of Eyeseryl: A Potent Eye Cream Ingredient

As a peptide expert in the medical field, I am often asked about the effectiveness of various ingredients in skincare products. One ingredient that has gained a lot of attention in recent years is Eyeseryl, a potent peptide that is widely used in eye creams. In this article, I will delve into the mechanism of action of Eyeseryl and explain how it can help improve the appearance of the delicate skin around the eyes.

What is Eyeseryl?

Eyeseryl is a tetrapeptide (a peptide consisting of four amino acids) known by its chemical name acetyl tetrapeptide-5. It is a synthetic peptide that has been specifically designed to target the appearance of puffiness and dark circles around the eyes. Eyeseryl is a trademarked ingredient developed by a leading supplier of peptides for the cosmetics industry.

Mechanism of Action

The effectiveness of Eyeseryl lies in its ability to improve the appearance of the skin through several key mechanisms of action:

Reduction of Fluid Accumulation

One of the primary causes of puffiness around the eyes is the accumulation of fluid in the under-eye area. Eyeseryl has been shown to reduce the permeability of blood vessels, which in turn helps to decrease the accumulation of fluid. This can lead to a reduction in the appearance of puffiness, giving the eyes a more refreshed and rejuvenated look.

Improvement in Microcirculation

Eyeseryl also has the ability to improve microcirculation in the under-eye area. This means that it can help to increase blood flow and oxygenation of the skin, which can in turn reduce the appearance of dark circles. By enhancing microcirculation, Eyeseryl can help to brighten the under-eye area and make it appear more youthful and vibrant.

Anti-inflammatory Properties

Inflammation can also contribute to the appearance of puffiness and dark circles around the eyes. Eyeseryl has been shown to possess anti-inflammatory properties, which can help to soothe and calm the delicate skin around the eyes. By reducing inflammation, Eyeseryl can contribute to a reduction in the appearance of puffiness and dark circles, leading to a more refreshed and revitalized appearance.

Evidence of Efficacy

Several clinical studies have been conducted to assess the efficacy of Eyeseryl in improving the appearance of the under-eye area. These studies have demonstrated promising results, showing that Eyeseryl can lead to a visible reduction in the appearance of puffiness and dark circles. Furthermore, these studies have also indicated that Eyeseryl is well-tolerated and safe for use in cosmetic products.

Application in Eye Creams

Due to its proven efficacy and safety profile, Eyeseryl has become a popular ingredient in eye creams and serums targeted at addressing concerns such as puffiness and dark circles. When selecting an eye cream containing Eyeseryl, it is important to look for products that are formulated with the appropriate concentration of the peptide to ensure optimal results.


Eyeseryl is a potent peptide ingredient that has been shown to effectively improve the appearance of puffiness and dark circles around the eyes. Its ability to reduce fluid accumulation, improve microcirculation, and possess anti-inflammatory properties makes it a valuable addition to skincare products, particularly eye creams. With a growing body of evidence supporting its efficacy, Eyeseryl is likely to continue to be a key ingredient in the formulation of effective and targeted eye treatments.

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